Neonatology Today
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چکیده
Data from four multicenter trials1-4 indicates that hypothermia is effective in diminishing brain injury in some neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE). Currently, hypothermia is emerging as a standard of care for certain neonates with HIE. Meta-analysis suggests the therapy may prevent long-term neurologic deficits in one neonate for every 8 treated.5 Since hypothermia does not help every neonate with HIE, the search for therapies to use in combination with hypothermia is currently a robust area of basic science research.6,7 As these therapies become available in the future, the need for multicenter trials exists because a single center does not have the capacity to enroll an adequate sample size to generate meaningful clinical results. Multicenter trials are slow to initiate because of variations in the hypothermia protocols among centers, as well as the variability in supportive care. These impediments were the driving force for the creation of the Florida Neonatal Neurologic Network. Backbone for Regionalization: The Florida Neonatal Neurologic Network Model
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Neonatology Today
The term, Hypoplastic Left Heart Syndrome (HLHS), initially proposed by Noonan and Nadas,8 describes a diminutive left ventricle with underdevelopment of mitral and aortic valves. A patent foramen ovale or an atrial septal defect is usually present. The ventricular septum is usually intact. A large patent ductus arteriosus supplies blood to the systemic circulation. Coarctation of the aorta is ...
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